Aortic banding in rat as a model to investigate malnutrition associated with heart failure.

  • Héliès-toussaint C
  • Moinard C
  • Rasmusen C
 et al. 
  • 14

    Readers

    Mendeley users who have this article in their library.
  • 21

    Citations

    Citations of this article.

Abstract

Heart failure is a severe pathology, which has displayed a dramatic increase in the occurrence of patients with chronic heart disease in developed countries, as a result of increases in the population's average age and in survival time. This pathology is associated with severe malnutrition, which worsens the prognosis. Although the cachexia associated with chronic heart failure is a well-known complication, there is no reference animal model of malnutrition related to heart failure. This study was designed to evaluate the nutritional status of rats in a model of loss of cardiac function obtained by ascending aortic banding. Cardiac overload led to the development of cardiac hypertrophy, which decompensates to heart failure, with increased brain natriuretic peptide levels. The rats displayed hepatic dysfunction and an associated renal hypotrophy and renal failure, evidenced by the alteration in renal function markers such as citrullinemia, creatininemia, and uremia. Malnutrition has been evidenced by the alteration of protein and amino acid metabolism. A muscular atrophy with decreased protein content and increased amino acid concentrations in both plasma and muscle was observed. These rats with heart failure displayed a multiorgan failure and malnutrition, which reflected the clinical situation of human chronic heart failure.

Author-supplied keywords

  • Amino Acids
  • Amino Acids: blood
  • Animal
  • Animals
  • Aorta
  • Aorta: surgery
  • Brain
  • Brain: blood
  • Creatine Kinase
  • Creatine Kinase: blood
  • Disease Models
  • Heart Failure
  • Heart Failure: complications
  • Heart Failure: metabolism
  • Heart Failure: physiopathology
  • Kidney
  • Kidney: physiopathology
  • Ligation
  • Liver
  • Liver: physiopathology
  • Male
  • Malnutrition
  • Malnutrition: etiology
  • Malnutrition: metabolism
  • Malnutrition: physiopathology
  • Natriuretic Peptide
  • Rats
  • Wistar

Get free article suggestions today

Mendeley saves you time finding and organizing research

Sign up here
Already have an account ?Sign in

Find this document

Authors

  • Cécile Héliès-toussaint

  • Christophe Moinard

  • Carole Rasmusen

  • Imène Tabbi-Anneni

  • Luc Cynober

  • Alain Grynberg

Cite this document

Choose a citation style from the tabs below

Save time finding and organizing research with Mendeley

Sign up for free