ApcMin: a mouse model for intestinal and mammary tumorigenesis.

  • Moser A
  • Luongo C
  • Gould K
 et al. 
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Min (multiple intestinal neoplasia) is a mutant allele of the murine Apc (adenomatous polyposis coli) locus, encoding a nonsense mutation at codon 850. Like humans with germline mutations in APC, Min/+ mice are predisposed to intestinal adenoma formation. The number of adenomas is influenced by modifier loci carried by different inbred strains. One modifier locus, Mom-1 (modifier of Min-1), maps to distal chromosome 4. Intestinal tumours from both B6 (C57BL/6J) and hybrid Min/+ mice show extensive loss of the wild-type allele at Apc. B6 Min/+ female mice are predisposed to spontaneous mammary tumours. The incidence of both intestinal and mammary tumours can be increased in an age-specific manner by treatment with ethylnitrosourea (ENU). Min mice provide a good animal model for studying the role of Apc and interacting genes in the initiation and progression of intestinal and mammary tumorigenesis.

Author-supplied keywords

  • APC
  • Adenomatous Polyposis Coli
  • Adenomatous Polyposis Coli: genetics
  • Animal
  • Animals
  • Disease Models
  • Experimental
  • Experimental: genetics
  • Female
  • Genes
  • Germ-Line Mutation
  • Inbred Strains
  • Mammary Neoplasms
  • Mice

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  • A R Moser

  • C Luongo

  • K A Gould

  • M K McNeley

  • A R Shoemaker

  • W F Dove

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