OBJECTIVE: The goal was to evaluate polymorphisms of the APOE gene as modifiers of neurobehavioral outcomes for preschool-aged children with congenital heart defects, after cardiac surgery. METHODS: A prospective observational study with neurodevelopmental evaluation between the fourth and fifth birthdays was performed. Attention and behavioral skills were assessed through parental report. RESULTS: Parents of 380 children completed the neurobehavioral measures. Child Behavior Checklist scores for the pervasive developmental problem scale were in the at-risk or clinically significant range for 15% of the cohort, compared with 9% for the normative data (P
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Gaynor, J. W., Nord, A. S., Wernovsky, G., Bernbaum, J., Solot, C. B., Burnham, N., … Gerdes, M. (2009). Apolipoprotein E genotype modifies the risk of behavior problems after infant cardiac surgery. Pediatrics, 124(1), 241–250. https://doi.org/10.1542/peds.2008-2281
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