Area postrema mediation of physiological and behavioral effects of lithium chloride in the rat

  • Bernstein I
  • Chavez M
  • Allen D
 et al. 
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Abstract

The area postrema (PA), a chemoreceptor trigger zone for nausea and vomiting, has been implicated in taste aversion conditioning with LiCl. In addition to taste aversion acquisition, the present studies indicate that a number of other responses to LiCl administration are eliminated by lesions of the AP. These include a behavioral response, 'lying-on-belly' as well as two physiological responses, delayed stomach emptying and hypothermia. These findings suggest that the area postrema is critically involved inn the detection of LiCl and in a wide range of responses to this toxin. They also provide strong evidence that the failure to acquire conditioned taste aversions to LiCl-paired flavors after AP lesions can be attributed to the absence of a significant 'illness' response in lesioned animals. © 1992.

Author-supplied keywords

  • Emetic mechanism
  • Gastric emptying
  • Hypothermia
  • Learned taste aversion

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Authors

  • Ilene L. Bernstein

  • Mark Chavez

  • Donald Allen

  • Eugene M. Taylor

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