Arousal and inhibition of human NK cells

  • Lanier L
  • Corliss B
  • Phillips J
  • 16

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Abstract

NK cells express receptors for polymorphic MHC class I molecules that inhibit killing of potential target cells bearing appropriate class I allotypes. Here we review the membrane receptors on human NK cells that are known to initiate cell-mediated cytotoxicity and demonstrate regulation of these responses by the killer cell inhibitory (KIR) receptors.

Author-supplied keywords

  • *Antigens, Ly
  • *Lymphocyte Activation/drug effects
  • Amino Acid Sequence
  • Humans
  • Killer Cells, Natural/drug effects/*metabolism
  • Lectins, C-Type
  • Membrane Glycoproteins/*physiology
  • Molecular Sequence Data
  • Receptors, Immunologic/*physiology
  • Receptors, NK Cell Lectin-Like
  • Suppressor Factors, Immunologic/*physiology

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Authors

  • L L Lanier

  • B Corliss

  • J H Phillips

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