Arterial chemoradiotherapy for carcinomas of the external auditory canal and middle ear

  • Fujiwara M
  • Yamamoto S
  • Doi H
 et al. 
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Abstract

OBJECTIVES/HYPOTHESIS: The purpose of this study was to estimate the efficacy of superselective arterial chemoradiotherapy for locally advanced carcinomas of the external auditory canal and middle ear.

STUDY DESIGN: A retrospective study of clinical data for consecutive patients with locally advanced carcinomas of the external auditory canal and middle ear.

METHODS: Thirteen patients with locally advanced carcinomas of the external auditory canal and middle ear (T3: one patient, T4: 12 patients) were reviewed. The median follow-up duration in the living patients was 33 months. The total dose of radiation therapy was 60 Gy using conventional fractionation. Four, five, or six courses of a superselective arterial infusion (cisplatin 50 mg) were given weekly.

RESULTS: The overall survival and progression-free survival rates at 2 years, calculated by the Kaplan-Meier method, were 58.7% and 53.8%, respectively. No late-phase adverse effects due to chemoradiation and no adverse effects due to catheterization were observed.

CONCLUSIONS: These results suggest that superselective arterial chemoradiation can be a treatment option for locally advanced carcinomas of the external auditory canal and middle ear.

LEVEL OF EVIDENCE: 4 Laryngoscope, 2014.

Author-supplied keywords

  • Arterial chemotherapy
  • Carcinomas of the external auditory canal and middle ear
  • Radiation therapy

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Authors

  • Masayuki Fujiwara

  • Satoshi Yamamoto

  • Hiroshi Doi

  • Yasuhiro Takada

  • Soichi Odawara

  • Yasue Niwa

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