Arterial stiffness and fetal growth in normotensive pregnancy

  • Elvan-Taşpinar A
  • Franx A
  • Bots M
 et al. 
  • 13

    Readers

    Mendeley users who have this article in their library.
  • 23

    Citations

    Citations of this article.

Abstract

Background: Normal pregnancy is characterized by a decrease in peripheral resistance and generalized vasodilation resulting in plasma volume expansion, which is associated with intrauterine growth. Stiffness of the arterial system may be a measure of the degree of plasma volume expansion. Pulse wave velocity (PWV), measured by applanation tonometry, is a validated approach to determine arterial stiffness. Pulse pressure (PP) is considered a surrogate measure for arterial stiffness. The aim of this study was to evaluate the association between arterial stiffness and fetal growth. Methods: In 50 normotensive pregnancies, carotid-femoral PWV was measured in the third trimester in 30° lateral position. Blood pressure measurements were performed with conventional auscultatory sphygmomanometry. Birth weight centiles and weight centiles at the age of 6 months were recorded. Linear regression models were used for statistical analyses. Results: There was a significant relationship in PWV with both birth weight centiles and catch-up growth after birth, independent of mean arterial pressure (MAP). An increase of 1 m/sec in PWV was associated with a decrease in birth weight centiles by 17.6% and a catch-up of 22.3% in weight centiles after birth. A stronger association was found for pulse pressure and birth weight centiles. An increase of 1 mm Hg was associated with a decrease in birth weight centiles by 1.8%. There was no association between MAP and birth weight centiles. Conclusions: In normotensive pregnancy arterial stiffness is associated with birth weight centile and catch-up growth after birth, independently from MAP. This suggests that arterial stiffness reflects maternal vascular adaptation to pregnancy better than blood pressure. © 2005 American Journal of Hypertension, Ltd.

Author-supplied keywords

  • Arterial stiffness
  • Intrauterine growth
  • Normotensive pregnancy

Get free article suggestions today

Mendeley saves you time finding and organizing research

Sign up here
Already have an account ?Sign in

Find this document

Authors

  • Ayten Elvan-Taşpinar

  • Arie Franx

  • Michiel L. Bots

  • Hein A. Koomans

  • Hein W. Bruinse

Cite this document

Choose a citation style from the tabs below

Save time finding and organizing research with Mendeley

Sign up for free