Arterolane, a new synthetic trioxolane for treatment of uncomplicated Plasmodium falciparum malaria: a phase II, multicenter, randomized, dose-finding clinical trial.

  • Valecha N
  • Looareesuwan S
  • Martensson A
 et al. 
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Abstract

Drug-resistant Plasmodium falciparum malaria necessitates development of novel drugs for treatment.The present study assessed the efficacy and safety of 3 dose levels of arterolane (RBx 11160), a synthetic trioxolane, for treatment of acute uncomplicated falciparum malaria.

Author-supplied keywords

  • 1 ring
  • 1 ring administration & d
  • 1 ring adverse effects
  • 1 ring pharmacology
  • adolescent
  • adult
  • aged
  • antimalarials
  • antimalarials administration & dosage
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  • antimalarials pharmacology
  • double blind method
  • falciparum
  • falciparum drug therapy
  • female
  • heterocyclic compounds
  • humans
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  • malaria
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  • peroxides
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  • plasmodium falciparum
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  • spiro compounds
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  • spiro compounds adverse effects
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  • tanzania
  • thailand
  • treatment outcome
  • young adult

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Authors

  • Neena Valecha

  • Sornchai Looareesuwan

  • Andreas Martensson

  • Salim Mohammed Abdulla

  • Srivicha Krudsood

  • Noppadon Tangpukdee

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