Artificial repressors for controlling gene expression in bacteria

  • Politz M
  • Copeland M
  • Pfleger B
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Abstract

Transcriptional repression is a common approach to control gene expression in synthetic biology applications. Here, an engineered DNA binding protein based upon a transcription activator-like effector (TALE) scaffold was shown to outperform LacI in blocking transcription from a promoter and to repress expression of a downstream gene in an operon.

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