Transcriptional repression is a common approach to control gene expression in synthetic biology applications. Here, an engineered DNA binding protein based upon a transcription activator-like effector (TALE) scaffold was shown to outperform LacI in blocking transcription from a promoter and to repress expression of a downstream gene in an operon. © 2013 The Royal Society of Chemistry.
CITATION STYLE
Politz, M. C., Copeland, M. F., & Pfleger, B. F. (2013). Artificial repressors for controlling gene expression in bacteria. Chemical Communications, 49(39), 4325–4327. https://doi.org/10.1039/c2cc37107c
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