Assessment of acute thermal nociception in laboratory animals.

  • Allen J
  • Yaksh T
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Abstract

Models of acute nociception using a thermal stimulus are widely employed as screening methods for nociceptive properties of new drug compounds. In this chapter, detailed descriptions for conducting of two of the most commonly used models; the hot plate test and the "Hargreaves test," are described. These models are applicable to both rats and mice and have the advantage of allowing repeated and multiple testing using a single animal because the stimulus is transitory and produces no tissue damage. Additionally, a modification of these models using a skin-twitch reflex that is applicable to large laboratory animals such a dogs or sheep is described. Guidance concerning potential confounding variable are discussed, as are tips for reducing variably among testing sessions.

Author-supplied keywords

  • c-fibers
  • dogs
  • hargreaves
  • hot plate
  • nociception
  • pain
  • rodents
  • skin
  • thermal

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Authors

  • Jeffrey W Allen

  • Tony L Yaksh

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