Assessment of longitudinal tissue Doppler imaging of the left ventricular septum and free wall as an indicator of left ventricular systolic function in dogs.

  • Hori Y
  • Sato S
  • Hoshi F
 et al. 
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OBJECTIVE: To evaluate tissue Doppler imaging (TDI) of the left ventricular
(LV) free wall (FW) and ventricular septum (VS) as an indicator of
LV systolic function in dogs. ANIMALS: 7 healthy Beagles. PROCEDURES:
Doses of dobutamine (5 and 10 microg/kg/min) and esmolol (50 and
100 microg/kg/min) were infused into the LV of each dog. With each
dose, heart rate; myocardial performance index (MPI); transmitral
inflow and ejection time (determined via pulsed-wave Doppler [PWD]
echocardiography); and FW and VS velocities of the mitral valve annulus
(determined via TDI during systole [S'], early diastole [E'], and
late diastole [A']) were assessed. RESULTS: With each dose, dobutamine
significantly increased heart rate and the first derivatives of LV
pressure (+dP/dt and -dP/dt), whereas esmolol significantly decreased
the +dP/dt and -dP/dt values, compared with baseline. Esmolol (100
microg/kg/min) significantly decreased the VS-TDI-derived S' velocity
and FW-TDI-derived E' velocity; dobutamine significantly increased
transmitral inflow and TDI velocities. Regression coefficient between
VS-TDI-derived S' velocity and +dP/dt was higher than that between
FW-TDI-derived S' velocity and +dP/dt. Compared with baseline, the
PWD- and VS-TDI-derived MPI were significantly decreased by dobutamine
and significantly increased by esmolol at each dose. Values of FW-TDI-derived
MPI were higher than values derived via the other techniques. Correlation
between +dP/dt and VS-TDI-derived MPI was greater than that between
In healthy dogs, the VS-TDI-derived S' velocity and MPI appear to
be reliable assessments for evaluating LV systolic function.

Author-supplied keywords

  • Adrenergic beta-Agonists
  • Doppler
  • Left
  • diagnostic use; Adrenergic beta-Antagonists
  • diagnostic use; Animals; Dobutamine
  • diagnostic use; Dogs
  • diagnostic use; Systole
  • drug effects/physiology
  • drug effects/physiology; Ventricular Function
  • methods/veterinary; Propanolamines
  • physiology; Echocardiography

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  • Yasutomo Hori

  • Shingo Sato

  • Fumio Hoshi

  • Sei-ichi Higuchi

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