Assisted assembly: How to improve a de novo genome assembly by using related species

  • Gnerre S
  • Lander E
  • Lindblad-Toh K
 et al. 
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Abstract

We describe a new assembly algorithm, where a genome assembly with low sequence coverage, either throughout the genome or locally, due to cloning bias, is considerably improved through an assisting process via a related genome. We show that the information provided by aligning the whole-genome shotgun reads of the target against a reference genome can be used to substantially improve the quality of the resulting assembly.

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Authors

  • Sante Gnerre

  • Eric S. Lander

  • Kerstin Lindblad-Toh

  • David B. Jaffe

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