Association between mild and severe hypoglycemia in patients with type 2 diabetes initiating insulin

  • A. F
  • R. D
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Abstract

The relationship between mild (MH) and severe hypoglycemia (SH) has been quantitatively evaluated in a randomized controlled, open-label, 2-arm, parallel study, in 2008 patients with type 2 diabetes initiating insulin (insulin glargine or insulin lispro mixture 25/75). Standard definitions were used for MH (all non-SH) and SH. A Cox regression model was employed to identify risk factors associated with incident SH. Average age was 56.90 (9.82) years, diabetes duration was 9.54 (6.10) years, BMI was 31.68 (5.96) kg/m2 and HbA1c was 9.03 (1.26)%. During a treatment period of 24 weeks, 78.6% (1606/2043) of the patients experienced more than one MH - but no SH - with a mean monthly MH rate (SD) of 2.67 (2.98). Thirty-three of 2043 patients (1.6%) experienced at least one SH with a mean monthly MH rate (SD) of 5.11 (3.98). Among all factors tested in the model, only the monthly MH rate (HR=1.174, CI [1.106, 1.248], p-value1.05) (Figure Presented).

Author-supplied keywords

  • *American
  • *diabetes mellitus
  • *human
  • *hypoglycemia
  • *insulin
  • *non insulin dependent diabetes mellitus
  • *patient
  • arm
  • hemoglobin A1c
  • insulin glargine
  • insulin lispro
  • model
  • proportional hazards model
  • risk
  • risk factor
  • statistical significance
  • stratification

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Authors

  • Festa A.

  • Duan R.

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