Association between polymorphisms in OAS2 and CD209 genes and predisposition to chronic hepatitis C in Russian population

  • Barkhash A
  • Kochneva G
  • Chub E
 et al. 
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Abstract

Chronic hepatitis C is a severe liver disease caused by positive-strand RNA virus. Previously, we reported an association between seven single nucleotide polymorphisms (SNPs) in four innate immunity genes (OAS2, OAS3, CD209, and TLR3) and human predisposition to tick-borne encephalitis, caused by a virus from the same Flaviviridae family, in a Russian population. Currently, genotype and allele frequencies for these SNPs were analyzed in 75 chronic hepatitis C patients and compared with the population control (269 Novosibirsk citizens). Data obtained suggest that the OAS2 rs1293762 and CD209 rs2287886 SNPs are associated with predisposition to chronic hepatitis C in Russian population. © 2014 Institut Pasteur.

Author-supplied keywords

  • Chronic hepatitis C
  • Genetic predisposition to disease
  • Single nucleotide polymorphism

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Authors

  • Andrey V. Barkhash

  • Galina V. Kochneva

  • Elena V. Chub

  • Svetlana V. Mikhailova

  • Aida G. Romaschenko

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