Association between vancomycin minimum inhibitory concentration and mortality among patients with staphylococcus aureus bloodstream infections: A systematic review and meta-analysis

  • Kalil A
  • Van Schooneveld T
  • Fey P
 et al. 
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Importance Staphylococcus aureus bacteremia (SAB) is a worldwide problem. It is unclear whether higher-vancomycin minimum inhibitory concentration (MIC) is associated with mortality. This potential association has direct consequences for patients and public health.Data Sources PubMed, Embase, the Cochrane Library, Evidence-based Medicine BMJ, and the American College of Physicians Journal Club were searched from inception through April 2014.Study Selection Studies reporting mortality and vancomycin MIC in patients with SAB were included.Data Extraction and Synthesis Two authors performed the literature search and the study selection separately. Random-effects modeling was used for all analyses.Main Outcomes and Measures All-cause mortality.Findings Among 38 included studies that involved 8291 episodes of SAB, overall mortality was 26.1%. The estimated mortality was 26.8% among SAB episodes (n = 2740) in patients with high-vancomycin MIC (≥1.5 mg/L) compared with 25.8% mortality among SAB episodes (n = 5551) in patients with low-vancomycin MIC (

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  • AC Kalil

  • TC Van Schooneveld

  • PD Fey

  • ME Rupp

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