Association of IL-10 and IL-10Rbeta gene polymorphisms with graft-versus-host disease after haematopoietic stem cell transplantation from an HLA-identical sibling donor.

  • Sivula J
  • Turpeinen H
  • Volin L
 et al. 
  • 18

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Abstract

Extensive allelic matching in the human leukocyte antigen (HLA) genes is regarded as a prerequisite for good clinical success of allogeneic haematopoietic stem cell transplantation (HSCT). Also other genetic factors can be assumed to play a role in preventing and controlling the complications associated with allogeneic HSCT, in particular graft-versus-host disease (GvHD). Interleukin-10 (IL-10) and its receptor (IL-10R), key regulators of the immune response, are among these candidates. We studied the association of IL-10 and IL-10Rbeta gene polymorphisms with the occurrence of GvHD in 309 HLA-identical sibling donor and recipient pairs.

Author-supplied keywords

  • Acute Disease
  • Adolescent
  • Adult
  • Aged
  • Child
  • Chronic Disease
  • Female
  • Genetic Predisposition to Disease
  • Genotype
  • Graft vs Host Disease
  • Graft vs Host Disease: etiology
  • Graft vs Host Disease: genetics
  • Graft vs Host Disease: immunology
  • HLA Antigens
  • HLA Antigens: genetics
  • HLA Antigens: immunology
  • Haplotypes
  • Hematologic Neoplasms
  • Hematologic Neoplasms: therapy
  • Hematopoietic Stem Cell Transplantation
  • Hematopoietic Stem Cell Transplantation: adverse e
  • Histocompatibility Testing
  • Humans
  • Interleukin-10
  • Interleukin-10 Receptor beta Subunit
  • Interleukin-10 Receptor beta Subunit: genetics
  • Interleukin-10 Receptor beta Subunit: immunology
  • Interleukin-10: genetics
  • Interleukin-10: immunology
  • Male
  • Middle Aged
  • Polymorphism, Genetic
  • Siblings

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Authors

  • Jyrki Sivula

  • Hannu Turpeinen

  • Liisa Volin

  • Jukka Partanen

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