The present study shows that rat liver and brain mitochondrial nitric oxide synthase (mtNOS) are functionally associated with mitochondrial respiratory chain complex I. When complex I is activated, mtNOS exerts high activity and generates nitric oxide, whereas inactivation of complex I leads mtNOS to abandon its NOS activity. Functional association of mtNOS with complex I is potentially important in regulating mtNOS activity and mitochondrial functions. © 2007 Elsevier Inc. All rights reserved.
CITATION STYLE
Parihar, M. S., Nazarewicz, R. R., Kincaid, E., Bringold, U., & Ghafourifar, P. (2008). Association of mitochondrial nitric oxide synthase activity with respiratory chain complex I. Biochemical and Biophysical Research Communications, 366(1), 23–28. https://doi.org/10.1016/j.bbrc.2007.11.056
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