Association of mitochondrial nitric oxide synthase activity with respiratory chain complex I

  • Parihar M
  • Nazarewicz R
  • Kincaid E
 et al. 
  • 11


    Mendeley users who have this article in their library.
  • 30


    Citations of this article.


The present study shows that rat liver and brain mitochondrial nitric oxide synthase (mtNOS) are functionally associated with mitochondrial respiratory chain complex I. When complex I is activated, mtNOS exerts high activity and generates nitric oxide, whereas inactivation of complex I leads mtNOS to abandon its NOS activity. Functional association of mtNOS with complex I is potentially important in regulating mtNOS activity and mitochondrial functions. © 2007 Elsevier Inc. All rights reserved.

Author-supplied keywords

  • Mitochondrial nitric oxide synthase
  • Mitochondrial respiration
  • Nitric oxide
  • Respiratory chain complex I

Get free article suggestions today

Mendeley saves you time finding and organizing research

Sign up here
Already have an account ?Sign in

Find this document

Get full text


  • Mordhwaj S. Parihar

  • Rafal R. Nazarewicz

  • Erick Kincaid

  • Urs Bringold

  • Pedram Ghafourifar

Cite this document

Choose a citation style from the tabs below

Save time finding and organizing research with Mendeley

Sign up for free