Association of mitochondrial nitric oxide synthase activity with respiratory chain complex I

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The present study shows that rat liver and brain mitochondrial nitric oxide synthase {(mtNOS)} are functionally associated with mitochondrial respiratory chain complex I. When complex I is activated, {mtNOS} exerts high activity and generates nitric oxide, whereas inactivation of complex I leads {mtNOS} to abandon its {NOS} activity. Functional association of {mtNOS} with complex I is potentially important in regulating {mtNOS} activity and mitochondrial functions.

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