Association screening of common and rare genetic variants by penalized regression

  • Zhou H
  • Sehl M
  • Sinsheimer J
 et al. 
  • 89

    Readers

    Mendeley users who have this article in their library.
  • 73

    Citations

    Citations of this article.

Abstract

MOTIVATION: This article extends our recent research on penalized estimation methods in genome-wide association studies to the realm of rare variants.

RESULTS: The new strategy is tested on both simulated and real data. Our findings on breast cancer data replicate previous results and shed light on variant effects within genes.

AVAILABILITY: Rare variant discovery by group penalized regression is now implemented in the free program Mendel at http://www.genetics.ucla.edu/software/.

Get free article suggestions today

Mendeley saves you time finding and organizing research

Sign up here
Already have an account ?Sign in

Find this document

Authors

  • Hua Zhou

  • Mary E. Sehl

  • Janet S. Sinsheimer

  • Kenneth Lange

Cite this document

Choose a citation style from the tabs below

Save time finding and organizing research with Mendeley

Sign up for free