MOTIVATION: This article extends our recent research on penalized estimation methods in genome-wide association studies to the realm of rare variants.
RESULTS: The new strategy is tested on both simulated and real data. Our findings on breast cancer data replicate previous results and shed light on variant effects within genes.
AVAILABILITY: Rare variant discovery by group penalized regression is now implemented in the free program Mendel at http://www.genetics.ucla.edu/software/.
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