Association screening of common and rare genetic variants by penalized regression

  • Zhou H
  • Sehl M
  • Sinsheimer J
 et al. 
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MOTIVATION: This article extends our recent research on penalized estimation methods in genome-wide association studies to the realm of rare variants.

RESULTS: The new strategy is tested on both simulated and real data. Our findings on breast cancer data replicate previous results and shed light on variant effects within genes.

AVAILABILITY: Rare variant discovery by group penalized regression is now implemented in the free program Mendel at

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  • Hua Zhou

  • Mary E. Sehl

  • Janet S. Sinsheimer

  • Kenneth Lange

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