Association of soluble HLA-G plasma levels with HLA-G alleles

  • Rebmann V
  • Van Der Ven K
  • Päßler M
 et al. 
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Abstract

Soluble HLA-G (sHLA-G) molecules are found in the peripheral blood of healthy females and males, in cord blood and in amniotic fluids and discussed to be a mediator in maternal-fetal tolerance. In this study we investigated whether there are allele-specific differences in expression of sHLA-G molecules. For this, the sHLA-G plasma concentrations of 94 healthy unrelated individuals were measured by ELISA and correlated to their HLA-G genotypes, as determined by sequence analysis of exon 2 and 3 of the HLA-G gene. Mean sHLA-G levels in individuals with the most common HLA-G alleles G*01011 (27.0+/-2.1 SEM ng/ml, n=66), G*01012 (28.4+/-3.2 SEM ng/ml, n=34) were very similar. In contrast, individuals carrying the HLA-G*01013 (8.1+/-1.7 SEM ng/ml, n=17) or the "null" allele HLA-G*0105N (8.2+/-3.2 SEM ng/ml, n=7) presented significantly (P(c)=0.001 and P(c)

Author-supplied keywords

  • HLA-G polymorphism
  • High sHLA-G secretor allele
  • Low sHLA-G secretor allele
  • Soluble HLA-G

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Authors

  • V. Rebmann

  • K. Van Der Ven

  • M. Päßler

  • K. Pfeiffer

  • D. Krebs

  • H. Grosse-Wilde

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