Associations between dietary habits and body mass index with gut microbiota composition and fecal water genotoxicity: an observational study in African American and Caucasian American volunteers

  • Mai V
  • McCrary Q
  • Sinha R
 et al. 
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BACKGROUND: African Americans (AA) suffer from an increased incidence and mortality of colorectal cancer (CRC). Environmental exposures including dietary habits likely contribute to a high burden of CRC, however, data on the dietary habits of AA is sparse. Diet might change the composition and the activities of the intestinal microbiota, in turn affecting fecal genotoxicity/mutagenicity that is thought to be associated with carcinogenesis. METHODS: We assessed dietary habits by food frequency questionnaire and by food records in 52 AA and 46 CA residents of the Eastern Shore of MD. Fecal microbiota composition was determined using 16S rRNA based methods and fecal genotoxicity measured using the Comet assay. RESULTS: AA reported an increased intake of heterocyclic amines and a decreased dietary intake of vitamins including vitamin D (p

Author-supplied keywords

  • Adult
  • African Americans
  • Bacteria
  • Body Mass Index
  • Calcium
  • Cell Survival
  • Colonic Neoplasms
  • DNA Damage
  • Diet
  • Environmental Exposure
  • European Continental Ancestry Group
  • Feces
  • Female
  • Food Habits
  • HT29 Cells
  • Humans
  • Incidence
  • Intestines
  • Male
  • Maryland
  • Microbiota
  • Middle Aged
  • Mutagenicity Tests
  • Mutagens
  • Obesity
  • Research
  • Vitamin D
  • Vitamins
  • Water
  • analysis
  • chemistry
  • ethnology
  • genetics
  • isolation & purification
  • metabolism
  • methods
  • microbiology
  • mortality

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  • PMID: 19845958


  • V Mai

  • Q M McCrary

  • R Sinha

  • M Glei

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