Associations of selenium status with cardiometabolic risk factors: an 8-year follow-up analysis of the Olivetti Heart study

  • Stranges S
  • Galletti F
  • Farinaro E
 et al. 
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OBJECTIVE: High selenium status has been associated with adverse cardiometabolic outcomes in selenium-replete populations such as the US. In populations with lower selenium status such as in Italy, there is little epidemiological evidence about the association of selenium with cardiometabolic risk factors. We therefore examined cross-sectional and prospective relationships of serum selenium concentrations with cardiometabolic risk factors including blood pressure, diabetes and blood lipids in the Olivetti Heart Study. METHODS: The study population consisted of 445 adult male individuals for whom baseline serum selenium measurement and cardiometabolic risk factors at baseline (1994-1995) and follow-up examination (2002-2004: average follow-up=8 years) were available. Serum selenium was measured by atomic absorption spectrophotometry. RESULTS: Average serum selenium concentration at baseline was 77.5 ± 18.4 μg/L. In cross-sectional analyses, serum selenium levels were positively associated with serum total cholesterol (p for trend

Author-supplied keywords

  • Adult
  • Aged
  • Atomic
  • Body Mass Index
  • Cardiovascular Diseases
  • Cross-Sectional Studies
  • Follow-Up Studies
  • Humans
  • Italy
  • Longitudinal Studies
  • Male
  • Middle Aged
  • Regression Analysis
  • Risk Factors
  • Selenium
  • Spectrophotometry
  • blood
  • diagnosis
  • methods

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  • S Stranges

  • F Galletti

  • E Farinaro

  • L D'Elia

  • O Russo

  • R Iacone

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