The astrocyte as a gatekeeper of synaptic information transfer

  • Volman V
  • Ben-Jacob E
  • Levine H
  • 90


    Mendeley users who have this article in their library.
  • 69


    Citations of this article.


We present a simple biophysical model for the coupling between synaptic transmission and the local calcium concentration on an enveloping astrocytic domain. This interaction enables the astrocyte to modulate the information flow from presynaptic to postsynaptic cells in a manner dependent on previous activity at this and other nearby synapses. Our model suggests a novel, testable hypothesis for the spike timing statistics measured for rapidly firing cells in culture experiments.

Get free article suggestions today

Mendeley saves you time finding and organizing research

Sign up here
Already have an account ?Sign in

Find this document


  • Vladislav Volman

  • Eshel Ben-Jacob

  • Herbert Levine

Cite this document

Choose a citation style from the tabs below

Save time finding and organizing research with Mendeley

Sign up for free