Attenuation of inflammation with short-term dietary intervention is associated with a reduction of arterial stiffness in subjects with hypercholesterolaemia

  • Pirro M
  • Schillaci G
  • Savarese G
 et al. 
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BACKGROUND: Increased arterial stiffness has been found in patients with chronic high-grade inflammatory diseases. Whether mitigation of low-grade systemic inflammation, through a low-cholesterol/low-saturated fat diet, may have a role in improving arterial stiffness is still untested. DESIGN: We investigated whether variations in blood lipids and plasma C-reactive protein induced by low-cholesterol/low-saturated fat diet are associated with variations in large-artery stiffness in hypercholesterolaemia. METHODS: Thirty-five patients with primary hypercholesterolaemia and 15 normal control subjects were recruited for the study. Hypercholesterolaemic patients followed an 8-week low-cholesterol/low-saturated fat diet (30% total fat, 5% saturated fat, cholesterol

Author-supplied keywords

  • exercise
  • heart failure
  • respiratory muscles

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  • Giuseppe Schillaci

  • Gianluca Savarese

  • Fabio Gemelli

  • Massimo Raffaele Mannarino

  • Donatella Siepi

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