Autoimmune ovarian disease induced by immunization with zona pellucida (ZP3) peptide.

  • Tung K
  • Agersborg S
  • Bagavant H
 et al. 
  • 33


    Mendeley users who have this article in their library.
  • 4


    Citations of this article.


Autoimmune ovarian disease is a known cause of human premature ovarian failure. An experimental murine model can be created by immunization with a peptide of ZP3, an ovary-specific glycoprotein. Mice injected with the ZP3 peptide develop histological evidence of ovarian inflammation (oophoritis), as well as antibody to the zona pellucida and T cell responses to the peptide. This unit describes the immunologic properties of the ZP3 peptides, the method of active autoimmune oophoritis induction, and the evaluation and semiquantitation of ovarian pathology. Surgical manipulations of the ovaries have been instrumental in the novel application of this autoimmune model; thus the most useful operations are also detailed. Surgical procedures are included for adult oophrectomy, neonatal ovariectomy, and implantation of ovarian grafts into mice without endogenous ovaries.

Author-supplied keywords

  • Animals
  • Autoimmune Diseases
  • Autoimmune Diseases: immunology
  • Autoimmune Diseases: pathology
  • Disease Models, Animal
  • Egg Proteins
  • Egg Proteins: immunology
  • Female
  • Immunization
  • Membrane Glycoproteins
  • Membrane Glycoproteins: immunology
  • Mice
  • Ovarian Diseases
  • Ovarian Diseases: immunology
  • Ovarian Diseases: pathology
  • Ovariectomy
  • Ovary
  • Ovary: transplantation
  • Receptors, Cell Surface
  • Receptors, Cell Surface: immunology
  • Transplants

Get free article suggestions today

Mendeley saves you time finding and organizing research

Sign up here
Already have an account ?Sign in

Find this document


  • Kenneth Tung

  • Sally Agersborg

  • Harini Bagavant

  • Kristine Garza

  • Kevin Wei

Cite this document

Choose a citation style from the tabs below

Save time finding and organizing research with Mendeley

Sign up for free