Azidoproline containing helices: Stabilization of the polyproline II structure by a functionalizable group

  • Kümin M
  • Sonntag L
  • Wennemers H
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Abstract

The conformation and functionalizability of 4-azidoproline containing polyprolines was studied. The conformational analyses demonstrate that the PPII helix is stabilized by (4R)Azp and destabilized by (4S)Azp. Functionalization of Azp containing polyprolines was accomplished efficiently in a differential fashion by ?click chemistry?, rendering Azp containing polyprolines attractive molecular scaffolds. The conformation and functionalizability of 4-azidoproline containing polyprolines was studied. The conformational analyses demonstrate that the PPII helix is stabilized by (4R)Azp and destabilized by (4S)Azp. Functionalization of Azp containing polyprolines was accomplished efficiently in a differential fashion by ?click chemistry?, rendering Azp containing polyprolines attractive molecular scaffolds.

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Authors

  • Michael Kümin

  • Louis Sebastian Sonntag

  • Helma Wennemers

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