BAALC-associated gene expression profiles define IGFBP7 as a novel molecular marker in acute leukemia.

  • Heesch S
  • Schlee C
  • Neumann M
 et al. 
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Abstract

Over expression of BAALC (brain and acute leukemia, cytoplasmic) predicts an inferior outcome in acute myeloid leukemia (AML) and acute lymphoblastic leukemia patients. To identify BAALC-associated genes that give insights into its functional role in chemotherapy resistance, gene expression signatures differentiating high from low BAALC expressers were generated from normal CD34(+) progenitors, T-acute lymphoblastic leukemia (T-ALL) and AML samples. The insulin-like growth factor binding protein 7 (IGFBP7) was one of the four genes (CD34, CD133, natriuretic peptide receptor C (NPR3), IGFBP7) coexpressed with BAALC and common to the three entities. In T-ALL, high IGFBP7-expression was associated with an immature phenotype of early T-ALL (P

Author-supplied keywords

  • Apoptosis
  • Base Sequence
  • Cell Line, Tumor
  • DNA Primers
  • DNA Replication
  • Gene Expression Profiling
  • Humans
  • Immunophenotyping
  • Insulin-Like Growth Factor Binding Proteins
  • Insulin-Like Growth Factor Binding Proteins: genet
  • Leukemia, B-Cell
  • Leukemia, B-Cell: genetics
  • Leukemia, Myeloid, Acute
  • Leukemia, Myeloid, Acute: genetics
  • Neoplasm Proteins
  • Neoplasm Proteins: genetics
  • Precursor T-Cell Lymphoblastic Leukemia-Lymphoma
  • Precursor T-Cell Lymphoblastic Leukemia-Lymphoma:
  • Tumor Markers, Biological

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Authors

  • S Heesch

  • C Schlee

  • M Neumann

  • a Stroux

  • a Kühnl

  • S Schwartz

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