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Journal article

Bactericidal/permeability-increasing protein (BPI) in sepsis correlates with the severity of sepsis and the outcome

Rintala E, Peuravuori H, Pulkki K, Voipio-Pulkki L, Nevalainen T ...see all

Intensive Care Medicine, vol. 26, issue 9 (2000) pp. 1248-1251

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Abstract

OBJECTIVE: To compare the prognostic significance of bactericidal/permeability-increasing protein (BPI), group II phospholipase A2 (PLA2-II), C-reactive protein (CRP), tumour necrosis factor-alpha (TNF), interleukin-8 (IL-8) and interferon-gamma (IFN) in terms of predicting severity of sepsis and outcome. DESIGN: A prospective study. SETTING: Medical intensive care unit (ICU) of a university hospital. PATIENTS: Thirty-four patients with severe sepsis requiring ICU treatment. MEASUREMENTS AND RESULTS: The levels of BPI, PLA2-II, CRP, TNF, IL-8 and IFN were measured in these 34 patients. High levels of BPI were associated particularly with Gram-negative sepsis. BPI and BPI/neutrophil ratios correlated positively with PLA2-II, CRP, TNF and IL-8 and negatively with blood pressure. At 24 h, BPI/neutrophil ratios, IL-8 and Simplified Acute Physiology Scores II (SAPS II) scores were higher in non-survivors than in survivors. No such associations were noted in the levels of CRP, PLA2-II, TNF or IFN. The areas under the curve (AUC(ROC)s) of SAPS II scores and IL-8 were higher than AUC(ROC) of BPI/neutrophil ratio. CONCLUSION: The BPI and BPI/neutrophil ratios may serve as adjunctive tools to illustrate the severity of sepsis. However, their predictive power for sepsis-related death was not comparable to that of SAPS II scores and IL-8.

Author-supplied keywords

  • Bactericidal/permeability-increasing protein
  • Creactive protein
  • Intensive care unit
  • Interleukin-8
  • Phospholipase A2
  • Sepsis

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Authors

  • Esa Rintala

  • Heikki Peuravuori

  • Kari Pulkki

  • Liisa Maria Voipio-Pulkki

  • Timo Nevalainen

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