Bacteriophage display and discovery of peptide leads for drug development.

  • Lowman H
  • 53

    Readers

    Mendeley users who have this article in their library.
  • 129

    Citations

    Citations of this article.

Abstract

Phage display makes large-peptide diversity libraries readily attainable for identifying novel peptide ligands for receptors and other protein or non-protein targets. This technology kindles enthusiasm for the idea that large and protein-protein interaction surfaces (epitopes) can be distilled down to small pharmacophores. These may be accessible to organic scaffolding, yielding new orally active drugs that might otherwise have taken greater time and effort to be discovered through chemical-library screening. This review, though not comprehensive with respect to the explosive volume of phage display work over the last few years, focuses on recent developments in phage-displayed peptide technology.

Author-supplied keywords

  • combinatorial library
  • drug
  • molecular mimicry
  • mutagenesis
  • structural biology

Get free article suggestions today

Mendeley saves you time finding and organizing research

Sign up here
Already have an account ?Sign in

Find this document

Authors

  • H B Lowman

Cite this document

Choose a citation style from the tabs below

Save time finding and organizing research with Mendeley

Sign up for free