Baseline demographics of the Valsartan Heart Failure Trial

  • Cohn J
  • Tognoni G
  • Glazer R
 et al. 
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Background: The Valsartan Heart Failure Trial (Val-HeFT) is the first large-scale randomized, multinational clinical study to assess the efficacy and safety of valsartan, an angiotensin II receptor blocker, added to conventional therapy, including angiotensin-converting enzyme inhibitors, in heart failure patients. A total of 5010 patients with an ejection fraction < 40% have been randomized to either valsartan titrated to 160 mg b.i.d. or to placebo. Aims: Baseline characteristics of patients in Val-HeFT are presented and compared with other major clinical trials in heart failure. Methods: Baseline data were collected and summary statistics calculated. Results: The Study population has a mean age of 62.7 years and is 80% male, 90.3% white, 6.9% black, and 2.8% Asian. Antecedent coronary heart disease is reported in 57.2% of patients. Angiotensin-converting enzyme inhibitors are prescribed for 92.7% of patients, diuretics for 85.8%, digoxin for 67.3%, and β-blockers for 35.6%. Subgroup comparisons by age, sex, race and ejection fraction quartile show small differences in baseline characteristics. Conclusion: Overall the Val-HeFT population is generally representative of the population of patients with mild to moderate heart failure in industrialized countries. (C) 2000 European Society of Cardiology.

Author-supplied keywords

  • Angiotensin receptor blocker
  • Baseline demographics
  • Clinical trial
  • Heart failure
  • Valsartan

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  • Jay N. Cohn

  • Gianni Tognoni

  • Robert Glazer

  • Dirk Spormann

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