Basic mechanisms responsible for osteolytic and osteoblastic bone metastases

  • Guise T
  • Mohammad K
  • Clines G
 et al. 
  • 155

    Readers

    Mendeley users who have this article in their library.
  • 291

    Citations

    Citations of this article.

Abstract

Certain solid tumors metastasize to bone and cause osteolysis and abnormal new bone formation. The respective phenotypes of dysregulated bone destruction and bone formation represent two ends of a spectrum, and most patients will have evidence of both. The mechanisms responsible for tumor growth in bone are complex and involve tumor stimulation of the osteoclast and the osteoblast as well as the response of the bone microenvironment. Furthermore, factors that increase bone resorption, independent of tumor, such as sex steroid deficiency, may contribute to this vicious cycle of tumor growth in bone. This article discusses mechanisms and therapeutic implications of osteolytic and osteoblastic bone metastases.

Get free article suggestions today

Mendeley saves you time finding and organizing research

Sign up here
Already have an account ?Sign in

Find this document

Authors

  • Khalid MohammadIndiana University

    Follow
  • Theresa A. Guise

  • Gregory Clines

  • Elizabeth G. Stebbins

  • Darren H. Wong

  • Linda S. Higgins

Cite this document

Choose a citation style from the tabs below

Save time finding and organizing research with Mendeley

Sign up for free