Baylis-Hillman adducts with molluscicidal activity against Biomphalaria glabrata

  • Vasconcellos M
  • Silva T
  • Camara C
 et al. 
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Abstract

The molluscicidal activities of ten Baylis-Hillman adducts against Biomphalaria glabrata (Say) snails, the intermediate host of schistosomiasis, have been determined. Nine of these compounds showed significant molluscicidal activity against B. glabrata, falling below the threshold of 100 microg ml(-1) set for potential molluscicidal activity by the World Health Organisation. Among these compounds, 3-hydroxy-2-methylene-3-(4-nitrophenyl)propanenitrile had the highest activity, with LC(50) = 6.64 microg ml(-1).

Author-supplied keywords

  • Baylis-Hillman reaction
  • Biomphalaria glabrata
  • Molluscicidal activity
  • Schistosomiasis

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Authors

  • Mário L.A.A. Vasconcellos

  • Celso A. Camara

  • Rodrigo M. Martins

  • Kelly M. Lacerda

  • Horacimone M. Lopes

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