Bcl11b is required for differentiation and survival of alphabeta T lymphocytes.

  • Wakabayashi Y
  • Watanabe H
  • Inoue J
 et al. 
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Abstract

The gene Bcl11b, which encodes zinc finger proteins, and its paralog, Bcl11a, are associated with immune-system malignancies. We have generated Bcl11b-deficient mice that show a block at the CD4-CD8- double-negative stage of thymocyte development without any impairment in cells of B- or gammadelta T cell lineages. The Bcl11b-/- thymocytes showed unsuccessful recombination of V(beta) to D(beta) and lacked the pre-T cell receptor (TCR) complex on the cell surface, owing to the absence of Tcrb mRNA expression. In addition, we saw profound apoptosis in the thymus of neonatal Bcl11b-/- mice. These results suggest that Bcl11b is a key regulator of both differentiation and survival during thymocyte development.

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Authors

  • Yuichi Wakabayashi

  • Hisami Watanabe

  • Jun Inoue

  • Naoki Takeda

  • Jun Sakata

  • Yukio Mishima

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