The BCL-2 Family Reunion

  • Chipuk J
  • Moldoveanu T
  • Llambi F
 et al. 
  • 514

    Readers

    Mendeley users who have this article in their library.
  • 765

    Citations

    Citations of this article.

Abstract

B cell CLL/lymphoma-2 (BCL-2) and its relatives comprise the BCL-2 family of proteins, which were originally characterized with respect to their roles in controlling outer mitochondrial membrane integrity and apoptosis. Current observations expand BCL-2 family function to include numerous cellular pathways. Here we will discuss the mechanisms and functions of the BCL-2 family in the context of these pathways, highlighting the complex integration and regulation of the BCL-2 family in cell fate decisions. © 2010 Elsevier Inc. All rights reserved.

Get free article suggestions today

Mendeley saves you time finding and organizing research

Sign up here
Already have an account ?Sign in

Find this document

Get full text

Authors

  • Jerry E. Chipuk

  • Tudor Moldoveanu

  • Fabien Llambi

  • Melissa J. Parsons

  • Douglas R. Green

Cite this document

Choose a citation style from the tabs below

Save time finding and organizing research with Mendeley

Sign up for free