The BCL-2 Family Reunion

  • Chipuk J
  • Moldoveanu T
  • Llambi F
 et al. 
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B cell CLL/lymphoma-2 (BCL-2) and its relatives comprise the BCL-2 family of proteins, which were originally characterized with respect to their roles in controlling outer mitochondrial membrane integrity and apoptosis. Current observations expand BCL-2 family function to include numerous cellular pathways. Here we will discuss the mechanisms and functions of the BCL-2 family in the context of these pathways, highlighting the complex integration and regulation of the BCL-2 family in cell fate decisions. © 2010 Elsevier Inc. All rights reserved.

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  • Jerry E. Chipuk

  • Tudor Moldoveanu

  • Fabien Llambi

  • Melissa J. Parsons

  • Douglas R. Green

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