Behavioral effects of autocerebral perfusion, hypothermia and arrest of cerebral blood flow in the rhesus monkey

  • Wolin L
  • Massopust L
  • White R
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Abstract

Monkeys (Macaca mulatta) were subjected to extracorporeal autocerebral perfusion. Ten animals had their brains cooled to 15 C and then maintained between 10 and 15 C for an additional 30 min by continued perfusion of cold blood. In ten animals, the brains were cooled to 15 C and cerebral blood fiow was then arrested for 30 min. Nine animals were perfused at normal temperatures for 1 hour as controls. Twenty-three of the 29 animals survived these procedures. Survivors were observed for 1 wk after surgery and revealed no obvious neurological deficits. Subsequent testing on a battery of behavioral tasks showed performance deficits suggestive of brain damage in only two animals, both from the control group. The incidence of death indicates the risk inherent in extracorporeal perfusion of the brain, but the long-term behavioral results found with the survivors demonstrates that profound hypothermia of the brain in and of itself does not have any apparently deleterious effects. Furthermore, the results with the animals subjected to arrest of cerebral blood flow under conditions of profound hypothermia demonstrate the protective effects of cooling against the damage which would otherwise result from ischemia and anoxia. © 1973.

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Authors

  • Lee R. Wolin

  • Leo C. Massopust

  • Robert J. White

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