Beta / Gamma EEG Activity in Patients with Primary and Secondary Insomnia and Good Sleeper Controls

  • Perlis M
  • Smith M
  • Andrews P
 et al. 
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Study Objective: Several studies have shown that patients with insomnia exhibit elevated levels of Beta EEG activity (14-35 Hz) at or around sleep onset and during NREM sleep. In this study, we evaluated 1) the extent to which high frequency EEG activity is limited to the 14-32 Hz domain, 2) whether high frequency EEG activity (HFA) is associated with discrepancies between subjective and PSG measures of sleep conti- nuity, and 3) the extent to which high frequency EEG activity occurs in patients with primary, as opposed to secondary, insomnia. Design: Three groups (n=9 per group) were compared: Primary Insomnia, Insomnia secondary to Major Depression, and Good Sleeper Controls. Groups were matched for age, sex and body mass. Average spectral profiles were created for each NREM cycle after removing waking and movement epochs and epochs containing micro- or mini-arousals. Setting: Sleep Research Laboratory Patients or Participants: Patients with primary and secondary insomnia Interventions: N/A Measurements and Results: Subjects with Primary Insomnia exhibited more average NREM activity for Beta-1 (14-20Hz), Beta-2 (20-35Hz) and Gamma activity (35-45Hz) than the other two groups (p.

Author-supplied keywords

  • beta
  • high frequency eeg
  • insomnia
  • power spectral analyses
  • sleep

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  • MIchael L Perlis

  • Michael T Smith

  • Patrick J Andrews

  • Henry Orff

  • Donna E Giles

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