Beyond DNA repair: DNA-PK function in cancer

  • Cottarel J
  • Frit P
  • Bombarde O
 et al. 
  • 1


    Mendeley users who have this article in their library.
  • N/A


    Citations of this article.


DNA double-stranded breaks (DSB) are among the most dangerous forms of DNA damage. Unrepaired DSBs results in cells undergoing apoptosis or senescence whereas mis-processing of DSBs can lead to genomic instability and carcinogenesis. One important pathway in eukaryotic cells responsible for the repair of DSBs is non-homologous end-joining (NHEJ). In this review we will discuss the interesting new insights into the mechanism of the NHEJ pathway and the proteins which mediate this repair process. Furthermore, the general role of NHEJ in promoting genomic stability will be discussed.

Author-supplied keywords

  • 1-Phosphatidylinositol 3-Kinase/classification/met
  • ALT
  • Animal
  • DNA Damage
  • DNA double strand breaks
  • DNA repair
  • DNA-Binding Proteins/metabolism/physiology
  • DNA-Ligase IV
  • DNA-PKcs
  • Enzyme Activation
  • Human
  • Knockout
  • Ku70/80
  • Mice
  • NIJ Final Grant Report
  • Non-U.S. Gov't
  • Nuclear Proteins/metabolism/physiology
  • Protein-Serine-Threonine Kinases/classification/*m
  • Signal Transduction
  • Support
  • Telomere
  • XLF
  • XRCC4
  • biochemistry
  • break-induced replication
  • chromosomes
  • damage checkpoint
  • dna damage
  • dna-
  • dsb repair
  • genes
  • homologous recombination
  • human
  • ku complex
  • non-homologous end-joining
  • nucleotide excision re-
  • pk
  • telomere

Get free article suggestions today

Mendeley saves you time finding and organizing research

Sign up here
Already have an account ?Sign in


  • Jessica Cottarel

  • Philippe Frit

  • Oriane Bombarde

  • Bernard Salles

  • Aurélie Négrel

  • Stéphanie Bernard

Cite this document

Choose a citation style from the tabs below

Save time finding and organizing research with Mendeley

Sign up for free