Use of big data in drug discovery and clinical trials

  • G. T
  • D.B. J
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Oncology is undergoing a data-driven metamorphosis. Armed with new and ever more efficient molecular and information technologies, we have entered an era where data is helping us spearhead the fight against cancer. This technology driven data explosion, often referred to as "big data", is not only expediting biomedical discovery, but it is also rapidly transforming the practice of oncology into an information science. This evolution is critical, as results to-date have revealed the immense complexity and genetic heterogeneity of patients and their tumors, a sobering reminder of the challenge facing every patient and their oncologist. This can only be addressed through development of clinico-molecular data analytics that provide a deeper understanding of the mechanisms controlling the biological and clinical response to available therapeutic options. Beyond the exciting implications for improved patient care, such advancements in predictive and evidence-based analytics stand to profoundly affect the processes of cancer drug discovery and associated clinical trials.

Author-supplied keywords

  • antineoplastic agent
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  • bioinformatics
  • cancer patient
  • clinical practice
  • clinical trial (topic)
  • drug development
  • endometrium carcinoma
  • evidence based practice
  • female genital tract cancer
  • genetic heterogeneity
  • health care
  • human
  • information science
  • medical informatics
  • medical record
  • mobile phone
  • nicotinamide adenine dinucleotide adenosine diphos
  • oncology
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  • personalized medicine
  • priority journal
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  • study design
  • tumor marker

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  • Taglang G.

  • Jackson D.B.

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