Binge drinking differentially affects adolescent male and female brain morphometry

  • Squeglia L
  • Sorg S
  • Schweinsburg A
 et al. 
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Rationale Adolescent binge drinking is concerning, as important neurodevelopments occur during this stage. Previous research suggests that binge drinking may disrupt typical brain development, and females may be particularly vulnerable. Objectives We used magnetic resonance imaging (MRI) to examine cortical thickness in adolescent females and males with and without histories of binge drinking. Methods Participants (N=59) were 16-19-year-old adolescents recruited from local schools. Recent binge drinkers (n= 29, 48% female) were matched to non-drinkers (n=30, 50% female) on age, gender, pubertal development, and familial alcoholism. Participants completed a neuropsychological battery and MRI session. Cortical surfaces were reconstructed with FreeSurfer. Results Binge × gender interactions (p

Author-supplied keywords

  • Adolescence
  • Adolescent
  • Adolescent Behavior
  • Alcohol
  • Alcohol Drinking
  • Alcohol use disorder
  • Binge
  • Brain
  • Cerebral Cortex
  • Cortical thickness
  • Cross-Sectional Studies
  • Female
  • FreeSurfer
  • Gender
  • Humans
  • Magnetic Resonance Imaging
  • Male
  • Neurodevelopment
  • Neuropsychological Tests
  • Risk Factors
  • Sex Factors
  • Young Adult
  • adolescent
  • adult
  • alcohol consumption
  • alcoholism
  • anterior cingulate
  • article
  • attention
  • brain development
  • brain function
  • brain region
  • brain size
  • controlled study
  • drinking behavior
  • executive function
  • female
  • gray matter
  • human
  • male
  • mental performance
  • morphometrics
  • neuroanatomy
  • neuropsychology
  • nuclear magnetic resonance imaging
  • orbital cortex
  • priority journal
  • risk factor
  • scoring system
  • sex difference

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  • L M Squeglia

  • S F Sorg

  • A D Schweinsburg

  • R R Wetherill

  • C Pulido

  • S F Tapert

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