Journal article

Bioactive Compounds from Marine Bacteria and Fungi

Debbab A, Aly A, Lin W, Proksch P ...see all

Microbial Biotechnology, vol. 3, issue 5 (2010) pp. 544-563

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Abstract

Marine bacteria and fungi are of considerable importance as new promising sources of a huge number of biologically active products. Some of these marine species live in a stressful habitat, under cold, lightless and high pressure conditions. Surprisingly, a large number of species with high diversity survive under such conditions and produce fascinating and structurally complex natural products. Up till now, only a small number of microorganisms have been investigated for bioactive metabolites, yet a huge number of active substances with some of them featuring unique structural skeletons have been isolated. This review covers new biologically active natural products published recently (2007-09) and highlights the chemical potential of marine microorganisms, with focus on bioactive products as well as on their mechanisms of action.

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Authors

  • Abdessamad Debbab

  • Amal H. Aly

  • Wen H. Lin

  • Peter Proksch

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