Bioactive meroterpenoids and alkaloids from the fungus Eurotium chevalieri

  • Kanokmedhakul K
  • Kanokmedhakul S
  • Suwannatrai R
 et al. 
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Five new meroterpenoids, chevalones A-D (1-4), aszonapyrone B (8), and a new sequiterpene alkaloid, eurochevalierine (5), together with four known compounds, sequiterpene (6), terpenoid pyrrolobenzoxazine named CJ-12662 (7), meroterpenoid, aszonapyrone A (9), and ergosterol were isolated from the fungus Eurotium chevalieri. The structures were established on the basis of spectroscopic evidence. The configurations of 1 and 5 were determined by X-ray analysis. The biosynthetic pathway of 1-3, 8, and 9 were proposed. Chemical transformation of aszonapyrone A (9) was also studied. Compounds 4, 5, and 7 exhibited antimalarial activity against Plasmodium falciparum, while 3, 5, and 7 showed antimycobacterial activity against Mycobacterium tuberculosis. In addition, compounds 2-7 showed cytotoxicity against cancer cell lines. © 2011 Elsevier Ltd. All rights reserved.

Author-supplied keywords

  • Anticancer
  • Antimalarial
  • Antimycobacterial
  • Aszonapyrone
  • Chevalones
  • Eurochevalierine
  • Eurotium chevalieri
  • Meroterpenoids

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