Bioactive potential of Streptomyces associated with marine sponges

  • Dharmaraj S
  • Sumantha A
  • 32


    Mendeley users who have this article in their library.
  • 20


    Citations of this article.


The present work deals with isolation of Streptomyces assocd. with marine sponges and its bioactive potential. Streptomyces sp. were isolated from the marine sponges Callyspongia diffusa, Mycale mytilorum, Tedania anhelans and Dysidea fragilis. From the initial screening, 94 cultures of Streptomyces were obtained and from these 58 cultures exhibited antagonism against bacteria, 36 strains against fungi and 27 strains exhibited broad spectrum activity against both. The submerged culture exts. of the 58 anti-bacterial isolates were analyzed and of these 58 strains, 37 strains showed pos. inhibition against Bacillus subtilis, 43 against Staphylococcus aureus, 10 against Vibrio cholerae and 10 against Escherichia coli. The antifungal activities of the 36 strains were also evaluated and 27 strains showed pos. inhibition against Aspergillus niger, 23 against Saccharomyces cerevisiae and 16 against Candida albicans. The prodn. of polyene substances from the active exts. was confirmed by UV spectral anal. by the absorbance peaks that ranged from 225 to 262 nm and the TLC (Rf values) ranging from 0.40 to 0.78. The results indicate that Streptomyces strains isolated from marine sponges produce potential antibacterial, antifungal and broad spectrum antibiotic compds. [on SciFinder(R)]

Author-supplied keywords

  • Actinobacteria
  • Bioactive compounds
  • Marine sponges
  • Streptomyces

Get free article suggestions today

Mendeley saves you time finding and organizing research

Sign up here
Already have an account ?Sign in

Find this document


  • Selvakumar Dharmaraj

  • Alagarsamy Sumantha

Cite this document

Choose a citation style from the tabs below

Save time finding and organizing research with Mendeley

Sign up for free