Bioanalytical strategies for in-vitro and in-vivo evaluation of the toxicity induced by metallic nanoparticles

  • Luque-Garcia J
  • Sanchez-Díaz R
  • Lopez-Heras I
 et al. 
  • 44

    Readers

    Mendeley users who have this article in their library.
  • 20

    Citations

    Citations of this article.

Abstract

The increasing use of metallic nanoparticles (MNPs) in a wide variety of applications has led to an urgent need to evaluate the impact of these new materials on human health and the environment. To date, the potential toxicity of MNPs and their interaction mechanisms with cells and living organisms have not been fully addressed.In this article, we discuss the different bioanalytical strategies that have been used for this purpose. We consider different methods aiming to evaluate cellular uptake and localization in cells and tissues, and in-vitro methods for the study of the toxicity induced by MNPs, considering different toxicity markers and high-throughput approaches for the identification of specific targets involved in the cell-MNP interaction. We also discuss special strategies related to the use of animal models to assess in-vivo toxicity of MNPs. © 2012 Elsevier Ltd.

Author-supplied keywords

  • Animal model
  • Bioanalytical strategy
  • Cellular uptake
  • In-vitro assay
  • In-vivo assay
  • Interaction mechanism
  • Metallic nanoparticle (MNP)
  • Target identification
  • Toxicity assessment
  • Toxicity marker

Get free article suggestions today

Mendeley saves you time finding and organizing research

Sign up here
Already have an account ?Sign in

Find this document

Authors

  • Jose L. Luque-Garcia

  • Raquel Sanchez-Díaz

  • Isabel Lopez-Heras

  • Carmen Camara

  • Pilar Martin

Cite this document

Choose a citation style from the tabs below

Save time finding and organizing research with Mendeley

Sign up for free