Bioavailability, Biodistribution and Toxicity of Biocal a new calcium source. Comparative studies in rats

  • Sarabia M
  • 5


    Mendeley users who have this article in their library.
  • N/A


    Citations of this article.


The purpose of this study is to determine the bioavailability, biodistribution and toxicity of Biocal™, a new calcium source. Biocal™ is a calcium gluconate stabilized with glycine. A comparative study of this compound versus calcium gluconate was performed in Sprague-Dawley rats. Bioavailability studies were carried out by the labeling of both compounds with 45Ca. We administered a dose of 30 mg of Ca per kg of body weight p.o. to two groups of 7 male adult rats each. The urine elimination of the 45Ca, expressed as total accumulated percentage of 45Ca activity in urine (Ae∞), between the rats that received Biocal™ (Ae∞ = 2.436±1.337 %) and the rats that received calcium gluconate (Ae∞ = 1.241±0.473 %) were found to be statistically different (p

Author-supplied keywords

  • Bioavailability
  • Calcium
  • Metabolism
  • Rat
  • Solubility
  • Toxicity

Get free article suggestions today

Mendeley saves you time finding and organizing research

Sign up here
Already have an account ?Sign in

Find this document

There are no full text links


  • M.I. Et Al. Sarabia

Cite this document

Choose a citation style from the tabs below

Save time finding and organizing research with Mendeley

Sign up for free