Bioavailability, Biodistribution and Toxicity of Biocal a new calcium source. Comparative studies in rats

  • Sarabia M
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Abstract

The purpose of this study is to determine the bioavailability, biodistribution and toxicity of Biocal™, a new calcium source. Biocal™ is a calcium gluconate stabilized with glycine. A comparative study of this compound versus calcium gluconate was performed in Sprague-Dawley rats. Bioavailability studies were carried out by the labeling of both compounds with 45Ca. We administered a dose of 30 mg of Ca per kg of body weight p.o. to two groups of 7 male adult rats each. The urine elimination of the 45Ca, expressed as total accumulated percentage of 45Ca activity in urine (Ae∞), between the rats that received Biocal™ (Ae∞ = 2.436±1.337 %) and the rats that received calcium gluconate (Ae∞ = 1.241±0.473 %) were found to be statistically different (p

Author-supplied keywords

  • Bioavailability
  • Calcium
  • Metabolism
  • Rat
  • Solubility
  • Toxicity

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Authors

  • M.I. Et Al. Sarabia

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