Biocompatibility and antimicrobial evaluation of montmorillonite/chitosan nanocomposites

  • Hsu S
  • Wang M
  • Lin J
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Abstract

Delaminated montmorillonite particles (DMtP) are novel two-dimensional nanomaterials. Chitosan (CS) is a biodegradable polysaccharide with good biocompatibility. New nanocomposites of CS and 10?104ppm of DMtP were prepared. The good dispersion of DMtP in the CS matrix was probably a result of the charge interaction between the two components. The nanocomposites demonstrated better dynamic mechanical moduli. DMtP were found to be enriched on the surface of the nanocomposites when the amount of DMtP was >103ppm. This was accompanied by a decrease of the contact angle. The proliferation of fibroblasts on DMtP/CS 103ppm was significantly greater than on other materials. The antimicrobial activity was enhanced markedly with the increased amount of DMtP in DMtP/CS. The inflammatory responses of DMtP in vitro and in subcutaneous rats were not obvious until the concentration of DMtP was >103ppm. The biocompatibility of DMtP/CS at 103ppm was even better than that of CS. The biodegradation rate of CS of the DMtP/CS nanocomposite was much faster than that of the pure CS polymer. These results suggested potential antimicrobial applications for DMtP/CS nanocomposites, especially for those containing 103ppm (0.1%) of DMtP. © 2011 Elsevier B.V.

Author-supplied keywords

  • Antimicrobial
  • Chitosan (CS)
  • Montmorillonite (Mt)
  • Nanocomposite

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Authors

  • Shan Hui Hsu

  • Ming Chien Wang

  • Jiang Jen Lin

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