Bioconcentration of ibuprofen in fathead minnow (Pimephales promelas) and channel catfish (Ictalurus punctatus)

  • Nallani G
  • Paulos P
  • Constantine L
 et al. 
  • 2


    Mendeley users who have this article in their library.
  • N/A


    Citations of this article.


Pharmaceutical products and their metabolites are being widely detected in aquatic environments and there is a growing interest in assessing potential risks of these substances to fish and other non-target species. Ibuprofen is one of the most commonly used analgesic drugs and no peer-reviewed laboratory studies have evaluated the tissue specific bioconcentration of ibuprofen in fish. In the current study, fathead minnow (Pimephales promelas) were exposed to 250??gL -1 ibuprofen for 28d followed by a 14d depuration phase. In a minimized bioconcentration test design, channel catfish (Ictalurus punctatus) were exposed to 250??gL -1 for a week and allowed to depurate for 7d. Tissues were collected during uptake and depuration phases of each test and the corresponding proportional and kinetic bioconcentration factors (BCFs) were estimated. The results indicated that the BCF levels were very low (0.08-1.4) implying the lack of bioconcentration potential for ibuprofen in the two species. The highest accumulation of ibuprofen was observed in the catfish plasma as opposed to individual tissues. The minimized test design yielded similar bioconcentration results as those of the standard test and has potential for its use in screening approaches for pharmaceuticals and other classes of chemicals. ?? 2011 Elsevier Ltd.

Author-supplied keywords

  • Bioconcentration
  • Channel catfish
  • Fathead minnow
  • Fish
  • Ibuprofen
  • Pharmaceuticals

Get free article suggestions today

Mendeley saves you time finding and organizing research

Sign up here
Already have an account ?Sign in

Find this document


  • G.C. Nallani

  • P.M. Paulos

  • L.A. Constantine

  • B.J. Venables

  • D.B. Huggett

Cite this document

Choose a citation style from the tabs below

Save time finding and organizing research with Mendeley

Sign up for free