See, stats, and : http : / / www . researchgate . net / publication / 8382574 Sonis , S . T . A . J . Support . 2 , 21 - 32 ARTICLE Source : PubMed CITATIONS 116 READS 263 1 : Stephen Brigham ' s 253 , 941 SEE Available : Stephen Retrieved : 30 21 VOLUME 2 , NUMBER 1 ■ JANUARY / FEBRUARY 2004 www . SupportiveOncology . net Abstract Oral mucositis is a common toxicity associated with both anti - neoplastic head and neck radiation and chemotherapy . In addition to exacting a terrible symptomatic toll , mucositis is associated with a num - ber of adverse health and economic outcomes . Furthermore , its presence may compromise the use of optimum agents , doses , or dosing sched - ules . The current lack of an approved , effective mucositis treatment has sparked interest in the development of interventions that are based on the biological mechanisms that lead to mucosal injury . While our un - derstanding of the molecular and cellular pathways leading to mucosi - tis is still evolving , it is now clear that the condition represents the cul - mination of a dynamic sequence of events that involve all cells and tissues in the mucosa . Five phases characterize the pathophysiologic progres - sion that results in mucositis : initiation , upregulation and message gen - eration , signaling and amplification , ulceration , and healing . Each phase offers a potential target for therapeutic intervention .
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