Are there biological markers of wear?

  • Bauer T
  • Shanbhag A
  • T.W. B
 et al. 
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Potential systemic markers of implant wear include products of the wear process (particles and ions) and mediators of the inflammatory reaction that can be induced by wear. Ions from polymers used in arthroplasty are not specific, but high metal ion levels may help identify patients with unexpectedly high wear of metal-on-metal implants. The kinetics of ion production, transport, and excretion are complex, however, so it is currently difficult to interpret the significance of mild elevations in metal ions. Indices of bone turnover (eg, collagen fragments) and mediators involved in the inflammatory reaction to particles (eg, osteoprotegerin, RANKL, interleukins) may be associated with osteolysis, but systemic disorders (eg, osteoarthritis) and the use of medications that influence bone remodeling limit the predictive value of these analytes with respect to the consequences of implant wear. Using genomic and proteomic methods to measure multiple analytes offers promise, but the challenge is to identify markers specifically associated with wear that are not elevated by other conditions that often coexist in this patient population.

Author-supplied keywords

  • *foreign body reaction/di [Diagnosis]
  • *hip arthroplasty/ae [Adverse Drug Reaction]
  • *hip prosthesis
  • *osteolysis/di [Diagnosis]
  • *osteolysis/et [Etiology]
  • *prosthesis failure
  • Arthroplasty
  • Biological Markers
  • Biological Markers: blood
  • Foreign-Body Reaction
  • Foreign-Body Reaction: diagnosis
  • Foreign-Body Reaction: immunology
  • Hip
  • Hip Prosthesis
  • Hip: adverse effects
  • Hip: instrumentation
  • Humans
  • Immunologic Factors
  • Immunologic Factors: blood
  • Mechanical
  • Metals
  • Metals: blood
  • Osteolysis
  • Osteolysis: diagnosis
  • Osteolysis: etiology
  • Osteolysis: immunology
  • Prosthesis Design
  • Prosthesis Failure
  • Replacement
  • Stress
  • article
  • biological marker
  • blood
  • human
  • immunologic factor
  • immunology
  • instrumentation
  • mechanical stress
  • metal
  • prosthesis

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  • ISSN: 1067-151X
  • PUI: 352408784
  • SGR: 52449103762
  • SCOPUS: 2-s2.0-52449103762
  • ISBN: 1067-151X
  • PMID: 18612017


  • Thomas W Bauer

  • Arun S Shanbhag

  • Bauer T.W.

  • Shanbhag A.S.

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