Biology and Applications of CRISPR Systems: Harnessing Nature's Toolbox for Genome Engineering.

  • Wright A
  • Nuñez J
  • Doudna J
 et al. 
  • 9


    Mendeley users who have this article in their library.
  • N/A


    Citations of this article.


Bacteria and archaea possess a range of defense mechanisms to combat plasmids and viral infections. Unique among these are the CRISPR-Cas (clustered regularly interspaced short palindromic repeats-CRISPR associated) systems, which provide adaptive immunity against foreign nucleic acids. CRISPR systems function by acquiring genetic records of invaders to facilitate robust interference upon reinfection. In this Review, we discuss recent advances in understanding the diverse mechanisms by which Cas proteins respond to foreign nucleic acids and how these systems have been harnessed for precision genome manipulation in a wide array of organisms.

Get free article suggestions today

Mendeley saves you time finding and organizing research

Sign up here
Already have an account ?Sign in

Find this document


  • Addison V Wright

  • James K Nuñez

  • Jennifer A Doudna

  • C. Anders

  • O. Niewoehner

  • A. Duerst

Cite this document

Choose a citation style from the tabs below

Save time finding and organizing research with Mendeley

Sign up for free