Bivalent Aptamers Deliver the Punch

  • Zhou J
  • Rossi J
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Aptamers, sometimes termed "chemical antibodies," have been engineered into multimerized versions for therapeutic application. The groups of Gilboa and Sullenger now report the development of a bivalent aptamer-molecular device as a receptor agonist that has the same functional properties, but stronger avidity than a corresponding antibody. © 2008 Elsevier Ltd. All rights reserved.

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  • Jiehua Zhou

  • John J. Rossi

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