Biventricular myocardial strain analysis in patients with arrhythmogenic right ventricular cardiomyopathy (ARVC) using cardiovascular magnetic resonance feature tracking

  • Heermann P
  • Hedderich D
  • Paul M
 et al. 
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BACKGROUND: Fibrofatty degeneration of myocardium in ARVC is associated with wall motion abnormalities. The aim of this study was to examine whether Cardiovascular Magnetic Resonance (CMR) based strain analysis using feature tracking (FT) can serve as a quantifiable measure to confirm global and regional ventricular dysfunction in ARVC patients and support the early detection of ARVC. METHODS: We enrolled 20 patients with ARVC, 30 with borderline ARVC and 22 subjects with a positive family history but no clinical signs of a manifest ARVC. 10 healthy volunteers (HV) served as controls. 15 ARVC patients received genotyping for Plakophilin-2 mutation (PKP-2), of which 7 were found to be positive. Cine MR datasets of all subjects were assessed for myocardial strain using FT (TomTec Diogenes Software). Global strain and strain rate in radial, circumferential and longitudinal mode were assessed for the right and left ventricle. In addition strain analysis at a segmental level was performed for the right ventricular free wall. RESULTS: RV global longitudinal strain rates in ARVC (-0.68 +/- 0.36 sec-1) and borderline ARVC (-0.85 +/- 0.36 sec-1) were significantly reduced in comparison with HV (-1.38 +/- 0.52 sec-1, p

Author-supplied keywords

  • arrhythmogenic right ventricular cardiomyopathy
  • arvc
  • cardiovascular magnetic resonance
  • correspondence
  • de
  • feature tracking
  • heermann
  • myocardial strain analysis
  • philipp
  • ukmuenster

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  • P Heermann

  • D M Hedderich

  • M Paul

  • C Schulke

  • J Kroeger

  • B Baessler

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